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Field Ionisation (FI) and Field Desorption (FD) were pioneered by H D Beckey in the late 1960’s as ionisation techniques that offered significant advantages over then current methods. The heart of the system is an emitter that has dendrites (cf conifers/evergreens) on it which have extremely small radii on their tips. These dendrites allow very high electric field strengths to be applied to a molecule. Source: Liquid Introduction Field Desorption Ionisation, University of Delaware.

Field Ionisation (FI) and Field Desorption (FD) were pioneered by H D Beckey in the late 1960’s as ionisation techniques that offered significant advantages over then current methods. The heart of the system is an emitter that has dendrites (cf conifers/evergreens) on it which have extremely small radii on their tips. These dendrites allow very high electric field strengths to be applied to a molecule.

Source: Liquid Introduction Field Desorption Ionisation, University of Delaware.

Diffusion Tensor Imaging (DTI): a magnetic resonance imaging technique that uses single-shot echo-planar MRI pulse sequences which have been optimized to detect the diffusivity of water molecules in tissue. By inducing magnetic gradients in different non-colinear directions while a subject is in the scanner, a series of diffusion weighted images (DWIs) can be acquired. For each given gradient, the echo attenuation values (ie “intensities”) at each voxel can then be used to calculate the apparent diffusion coefficient (ADC). The set of ADCs for each voxel can be used in turn to calculate the diffusion tensor for that voxel, an ellipsoid which models the diffusion profile of water within that voxel. The eccentricity of the ellipsoid is known as the Fractional Anisotropy (FA); the mean of the three principle eigenvectors is known as the mean diffusivity (MD). Source&Credit: DTI Notes, Jesse Brown, UCLA

Diffusion Tensor Imaging (DTI): a magnetic resonance imaging technique that uses single-shot echo-planar MRI pulse sequences which have been optimized to detect the diffusivity of water molecules in tissue. By inducing magnetic gradients in different non-colinear directions while a subject is in the scanner, a series of diffusion weighted images (DWIs) can be acquired. For each given gradient, the echo attenuation values (ie “intensities”) at each voxel can then be used to calculate the apparent diffusion coefficient (ADC). The set of ADCs for each voxel can be used in turn to calculate the diffusion tensor for that voxel, an ellipsoid which models the diffusion profile of water within that voxel. The eccentricity of the ellipsoid is known as the Fractional Anisotropy (FA); the mean of the three principle eigenvectors is known as the mean diffusivity (MD).

Source&Credit: DTI Notes, Jesse Brown, UCLA

Spatially realistic cell modeling centers on realistic 3-D simulations of movements and reactions of molecules within and between cells, to better understand physiological function and disease. MCell, DReAMM and PSC_DX software is developed at the NRBSC and used to model and visualize events such as this image (closeup and zoomed out), which represents neurotransmitter release in one dendritic spine. Source: Research Notes & Highlights, 2008, Projects in Scientific Computing, Pittsburgh Supercomputing Center

Spatially realistic cell modeling centers on realistic 3-D simulations of movements and reactions of molecules within and between cells, to better understand physiological function and disease. MCell, DReAMM and PSC_DX software is developed at the NRBSC and used to model and visualize events such as this image (closeup and zoomed out), which represents neurotransmitter release in one dendritic spine.

Source: Research Notes & Highlights, 2008, Projects in Scientific Computing, Pittsburgh Supercomputing Center